• David I. Pryor David I. Pryor
  • Sandro V. Porceddu Sandro V. Porceddu
  • Paul Scuffham Paul Scuffham
  • Jennifer Whitty Jennifer Whitty
  • Paul A. Thomas Paul A. Thomas
  • Bryan H. Burmeister Bryan H. Burmeister

Background The aim of this economic alysis was to model different strategies using pre-treatment nodal stage or nodal response assessment with CT or positron emission tomography (PET)/CT to determine the need for neck dissection. Methods A cost-minimization alysis was developed on the basis of probability data from a prospective study of PET-guided magement of the neck in patients achieving a complete response at the primary site. Costs were derived from our institution's activity-based clinical costing system. The effect of uncertainty was tested with sensitivity and scerio alyses including tiolly representative cost data. Results Strategies incorporating PET had a 7% rate for neck dissection compared with 44% for CT-guided and 90% for planned neck dissection. The cost per patient was A$16,502 for planned neck dissection, A$8014 for CT-guided, and A$2573 for PET-guided. A policy with PET used only for incomplete response on CT was the least-cost strategy (A$2111). Policies incorporating PET remained the most efficient for all sensitivity/scerio alyses. Conclusion The incorporation of PET/CT into nodal response assessment significantly reduced the number of unnecessary neck dissections and generated considerable cost savings in our cohort. 頲012 Wiley Periodicals, Inc. Head Neck, 2013