This study investigated persol and social processes of adjustment at different stages of illness for individuals with brain tumour. A purposive sample of 18 participants with mixed tumour types (9 benign and 9 malignt) and 15 family caregivers was recruited from a neurosurgical practice and a brain tumour support service. In-depth semi-structured interviews focused on participants' perceptions of their adjustment, including persol appraisals, coping and social support since their brain tumour diagnosis. Interview transcripts were alysed thematically using open, axial and selective coding techniques. The primary theme that emerged from the alysis entailed "key sense making appraisals", which was closely related to the following secondary themes: (1) Interactions with those in the healthcare system, (2) reactions and support from the persol support network, and (3) a diversity of coping efforts. Adjustment to brain tumour involved a series of appraisals about the illness that were influenced by interactions with those in the healthcare system, reactions and support from people in their support network, and persol coping efforts. Overall, the findings indicate that adjustment to brain tumour is highly individualistic; however, some common persol and social processes are evident in how people make sense of and adapt to the illness over time. A prelimiry framework of adjustment based on the present findings and its clinical relevance are discussed. In particular, it is important for health professiols to seek to understand and support individuals' sense-making processes following diagnosis of brain tumour.