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Overview

Current Work

Dr Gopalan is a Senior Lecturer in Histopathology in Schools of Medicine and Medical Sciences. Dr Gopalan’s research focuses on the molecular interactions and its clinical implications in human cancers with particular interests in cancers of the gastrointestinal tract and endocrine organs. Dr Gopalan is one of the Research Leaders in the Cancer Molecular Pathology Laboratory of Menzies Health Institute Queensland. His research laboratory is conjointly run by Anatomical Pathologists and Surgeons from the Gold Coast University Hospital along with Griffith University academics. Dr Gopalan’s research investigates many human cancer tissues and blood samples for identifying new markers in Angiogenesis and Cancer Metastasis. Dr Gopalan has published >90 peer-reviewed research articles in respected journals such as Molecular Carcinogenesis, Molecular Oncology, Journal of Gastroenterology and Scientific Reports. Also, he has obtained over $250,000 in research and teaching grants with an H-index of 17. Recently he has received many awards and achievements such as Certificate award of Academic Appreciation- 2017; Excellence in Publication Award- 2017; Pink and Purple Heart Award- 2016; Learning and Teaching Citation Award- 2015; PVC Early Career Research Award- Highly commended- 2014 and Excellence in Team or Group research- Highly commended- 2014. Dr Gopalan is currently supervising many PhD, MPhil and Master/Honors students in Menzies Health Institute at Griffith University.

Current Appointments:
Senior Lecturer in Medical Education and Histopathology
School of Medicine & Medical Science
 

News

Subject Area Codes

  • Cancer Cell Biology
  • Cancer Genetics
  • MEDICAL AND HEALTH SCIENCES
  • Molecular Medicine
  • Molecular Targets
  • Pathology

Country Affiliations

  • China
  • Hong Kong
  • Iran
  • Japan

Research Publications and Outputs

Recent Publications

Publications: 100 (Other: 100)

Funded Griffith Research

Engagement and Impact

Invitations

  • Panelist
    Review and Accreditation of School of Medical and Applied Sciences,   Central Queensland University, Rockhampton, QLD.,   2016,  
  • Speech
    Novel Molecular Markers in the Pathogenesis of Colorectal Cancers,   Japanese Society of Pathology,   2016,  
    A major effort in our group is the identification of novel genetic markers that can be used as a prognostic or predictive marker in colorectal adenocarcinomas. We use different technologies for candidate biomarker identification, and subsequently study the biological function of these markers and their expression in large panel of tumour tissues samples. Cluster of miRNAs regulating the mitochondrial respiration and cancer stemness by various biological process were identified. Our previous research using genetic fingerprinting has revealed two genetic markers, GAEC1 and FAM134B with oncogenic and tumour suppressor properties respectively. The pathogenic effects of these markers and mitochondrial miRNAs were confirmed by in-vitro and in-vivo analysis. Clinical validation of these markers including its prognostic significance was done in a large series of matched cancer tissue samples on mRNA and protein levels. Subsequent findings on these markers were published in Nature and Nature Genetics. Also we have reported the novel mutation sites in GACE1 and FAM134B and its clinical implications for the first time in cancers. Digital PCR was used to identify the absolute quantification of copy number variations in these markers. Expression, localisation and pattern variation were noted in peripheral blood samples using various markers such as CD45, CD19, CD3 and CD16. In addition, possible downstream signalling pathways were mapped following the functional studies.
  • Other
    Ambasador,   European Association of Cancer Research (EACR),   2015,  
    Student Ambasador for EACR in Australia to enhance and collaborate cancer researchers and students from Australia to Europe
  • Panelist
    University Bio-safety Committee (UBC),   Griffith University,   2015,  
    Panel member and reviewer for UBC applications
  • Panelist
    Human Research Ethic Committee,,   Gold Coast University Hospital, Queensland Health.,   2015,  
    Full Committee Member for Human Research Ethics Applications in Gold Coast.
  • External examiner PhD
    PhD exam reviewer,   Queensland University of Technology, Bond University.,   2014,  

Learning and Teaching

Current and Past Courses

  • Medicine 2 (8002MED_Y1)
    Teacher, In Person, In Field, Gold Coast Campus, Semester 1, 2019.
  • Medicine 1 (8001MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2018.
  • Medicine 1 (8001MED_Y1)
    Teacher, In Person, In Field, Gold Coast Campus, Semester 1, 2018.
  • Histopathology (3008MSC)
    Convenor, In Person, Gold Coast Campus, Semester 2, 2018.
  • Histopathology (3008MSC)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2018.
  • Medicine 2 (8002MED_Y1)
    Teacher, In Person, In Field, Gold Coast Campus, Semester 1, 2018.
  • Medicine 2 (8002MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2018.
  • Medicine 1 (8001MED_Y2)
    Teacher, In Person, Other Campus, Semester 2, 2018.
  • Medicine 1 (8001MED_Y1)
    Teacher, In Person, In Field, Other Campus, Semester 1, 2018.
  • Medicine 1 (8001MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2017.
  • Medicine 1 (8001MED_Y1)
    Teacher, In Person, In Field, Gold Coast Campus, Semester 1, 2017.
  • Histopathology (3008MSC)
    Convenor, In Person, Gold Coast Campus, Semester 2, 2017.
  • Histopathology (3008MSC)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2017.
  • Integrative Medical Sciences (3000MSC)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2017.
  • Integrative Medical Sciences (3000MSC)
    Teacher, In Person, Intensive, Gold Coast Campus, Semester 2, 2017.
  • Medicine 2 (8002MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2017.
  • Medicine 1 (8001MED_Y2)
    Teacher, In Person, Other Campus, Semester 2, 2017.
  • Medicine 1 (8001MED_Y1)
    Teacher, In Person, In Field, Other Campus, Semester 1, 2017.
  • Medicine 1 (8001MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2016.
  • Histopathology (3008MSC)
    Convenor, In Person, Gold Coast Campus, Semester 2, 2016.
  • Histopathology (3008MSC)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2016.
  • Medicine 2 (8002MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2016.
  • Medicine 1 (8001MED_Y2)
    Teacher, In Person, Other Campus, Semester 2, 2016.
  • Medicine 1 (8001MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2015.
  • Histopathology (3008MSC)
    Convenor, In Person, Gold Coast Campus, Semester 2, 2015.
  • Histopathology (3008MSC)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2015.
  • Medicine 2 (8002MED_Y1)
    Teacher, In Person, In Field, Gold Coast Campus, Semester 1, 2015.
  • Medicine 2 (8002MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2015.
  • Medicine 1 (8001MED_Y2)
    Teacher, In Person, Other Campus, Semester 2, 2015.
  • Medicine 1 (8001MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2014.
  • Medicine 1 (8001MED_Y1)
    Teacher, In Person, In Field, Gold Coast Campus, Semester 1, 2014.
  • Histopathology (3008MSC)
    Convenor, In Person, Gold Coast Campus, Semester 2, 2014.
  • Histopathology (3008MSC)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2014.
  • Medicine 2 (2001MED_Y1)
    Teacher, In Person, Gold Coast Campus, Semester 1, 2014.
  • Medicine 2 (2001MED_Y1)
    Teacher, In Person, In Field, Gold Coast Campus, Semester 1, 2014.
  • Medicine 2 (2001MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2014.
  • Medicine 2 (2001MED_Y2)
    Teacher, In Person, In Field, Gold Coast Campus, Semester 2, 2014.
  • Medicine 2 (8002MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2014.
  • Medicine 1 (8001MED_Y2)
    Teacher, In Person, Other Campus, Semester 2, 2014.
  • Medicine 1 (8001MED_Y1)
    Teacher, In Person, In Field, Other Campus, Semester 1, 2014.
  • Histopathology (3008MSC)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2013.
  • Medicine 1 (1001MED_Y1)
    Teacher, In Person, Gold Coast Campus, Semester 1, 2013.
  • Medicine 1 (1001MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2013.
  • Medicine 2 (2001MED_Y1)
    Teacher, In Person, Gold Coast Campus, Semester 1, 2013.
  • Medicine 2 (2001MED_Y1)
    Teacher, In Person, In Field, Gold Coast Campus, Semester 1, 2013.
  • Medicine 2 (2001MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2013.
  • Medicine 2 (2001MED_Y2)
    Teacher, In Person, In Field, Gold Coast Campus, Semester 2, 2013.
  • Medicine 3 (3001MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2013.
  • Medicine 3 (3001MED_Y2)
    Teacher, In Person, In Field, Gold Coast Campus, Semester 2, 2013.
  • Medicine 1 (1001MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2012.
  • Pathology General (2006MED)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2012.
  • Medicine 2 (2001MED_Y2)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2012.
  • Medicine 2 (2001MED_Y2)
    Teacher, In Person, In Field, Gold Coast Campus, Semester 2, 2012.
  • Pathology General (2006MED)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2011.

Research by Higher Degree Supervision or Scholarship

Supervision Overview

PRINCIPAL RESEARCH SUPERVISION

Post-doctoral Research Fellow:Dr Hirotaka Ishida MD, PhD. Funding collaboration with Tohoku Medical University, Japan. 2 years full time (April 2018-May 202).

HDR COMPLETIONS

Principal Supervision

Dr Riajul Wahab: PhD Thesis- Molecular Characterisation of GAEC1 oncogene and its functional and clinical implications in colorectal cancers. Finish Date: June 2018

Dr Afraa J Mamoori: PhD Thesis-The role of stem cell regulated miRNAs in colorectal cancers. Finish Date: March 2018Current progress- Assistant Professor, University of Babylon, Iraq

Dr Farhadul Islam: PhD Thesis- Molecular Characterisation of JK1 gene in colorectal cancers and its functional and cellular characteristics. Finish Date- Jan 2018
Current progress- Associate Professor, University of Rajshahi, Bangladesh

Dr Hakimul Haque: PhD Thesis- Investigating the role of FAM134B mutation in gastrointestinal cancers. Finish Date- June 2017. Current progress- Associate Professor, University of Rajshahi, Bangladesh

Associate Supervision

Dr Hamidreza Maroof: PhD Thesis- Investigating the role of miRNA-34 family in human thyroid cancer. Finish Date- Feb 2018. Current progress- Post-doc, Federation University Australia

Master/Honors completions

Ms Karishma Sajnani:Thesis- Investigating the role of novel genetic mutations in the progression of pheochromocytoma. Finish Date: Mar 2016 (Graduated with High Distinction). Current progress- PhD Student, India

Ms.Omel Qallander: Thesis- Investigating the bone invasive properties of ameloblastoma- Finish Date- Dec 2015. (Graduated with High Distinction). Current progress- Dentistry student, Griffith University

Mr. Madison Orr: Thesis- Detection of GAEC1 in peripheral blood cells and its clinical implications in colorectal cancers. Finish Date- Feb 2015. Graduated with Distinction
Current progress- Research assistant, Sydney

Dr Luqman Jubair: Thesis-The cultural, social and religious determinants of cervical cancer screening in patients attending Alkadhamia Teaching Hospital, Iraq.
Finish Date: Dec 2014. Graduated with Distinction. Current progress- PhD student, Griffith University

Ms Shelle Nordstrom: Thesis- Role of miR-1288 in metastatic colorectal cancers.
Finish Date: Jan 2014. Graduated with Distinction. Current progress- Medicine (MD), Flinders University, Australia

Ms Faeza Ebrahimi: Thesis- Expression profiling of miR-126 in colorectal cancer patients. Finish Date: Aug 2013. Graduated with Distinction. Current progress- PhD and Dental student.

CURRENT PRINCIPAL HDR SUPERVISION

(1) Ms Faeza Qallandar: PhD Thesis- Mitochondrial miRNAs and their regulation in colorectal cancer metastasis: Start Date-Feb 2014. Progress-Thesis examination

(2) Ms Katherine Lee: PhD Thesis- Genotyping and investigating the interaction partners of GAEC1 in colorectal cancer pathogenesis. Start Date- Mar 2015.
Progress- Thesis due to submit Nov 2018

(3) Ms Anna Chruscik: PhD Thesis- Investigating the novel genetic interactions in colon cancer stem cell pathways. Start Date- March 2015. Progress- Thesis due to submit Feb 2019

(4) Faysal-Bin Hamid: PhD Thesis-Circulating tumor cells and cell free DNA and its clinicopathological implications in colorectal cancers. Start Date- April 2017. Progress- PhD confirmed, May 2018

(5) Dr Ian Brown: PhD by Publication- Start Date- July 2017. Progress- MBBS, FRCPA, Pathology consultant

(6) Ms Tracie Cheng: PhD Thesis-Investigating the molecular and cellular implications of red/processed meat molecules in bowel cancers. Start Date- Feb 2018
Progress- Confirmation due in 8 months

Background

Bio

Dr Gopalan is a Senior Lecturer in Histopathology and Medical Education and an early career researcher in Schools of Medicine and Medical Sciences. He has obtained his PhD in the field of Molecular Pathology in School of Medicine, Griffith University. Dr Gopalan’s research focuses on the histopathological, molecular and clinical implications of human cancers especially solid tumors in the Gastrointestinal tract, Endocrine and Head and Neck regions. Dr Gopalan is one of the Research Leaders in the Cancer Molecular Pathology Laboratory of Menzies Health Institute Queensland (MHIQ). His research laboratory is conjointly run by Anatomical Pathologists and Surgeons from the Gold Coast University Hospital along with Griffith University academics. Dr Gopalan’s research investigates many human cancer tissues and blood samples for identifying new markers in Angiogenesis and Cancer Metastasis.

Dr Gopalan has published more than 40 peer-reviewed research articles in respected journals such as Cancer Research, Molecular Carcinogenesis, Molecular oncology, Biology of the Cell and Journal of Clinical Pathology. Also, he has obtained over $200,000 in research and teaching grants over last 6 years. Recently he has received many awards and achievements such as Learning and Teaching citation award- 2015, PVC Early Career Research Award- Highly commended, 2014 and Excellence in Team or Group research- Highly commended, 2014. Dr Gopalan is currently supervising 8 PhD, MPhil and Master/Honors students in MHIQ.
 

Education and Training

  • MS Master of Science, School of Medicine/Medical Science, Griffith University 2008 - 2009
  • PhD Doctor of Philosophy, School of Medicine, Griffith University 2010 - 2013

External service roles

  • Review Panelist, Human Research Ethic Committee (HREC), Gold Coast University Hospital, Queensland Health 2014 - Present
  • Ambassador, European Association of Cancer Research (EACR), Nottingham, United Kingdom. 2013 - Present