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Overview

Current Work

Prof McMillan is a cancer researcher interested in the infectious causes of cancer. Nearly ⅓ of all cancers are caused by viruses, bacteria and other microorganisms. He is an internationally recognised expert in the area of human papillomavirus, gene editing and gene silencing. He has over 90 publications and has had continuous NHRMC funding for 22 years. He has graduated over 40 Masters or Honours students and 22 PhD students.  

News

Research Publications and Outputs

Recent Publications

Publications: 54 (Other: 54)

Funded Griffith Research

Engagement and Impact

Learning and Teaching

Current and Past Courses

  • Molecular Biology (3014MSC)
    Teacher, In Person, Gold Coast Campus, Semester 1, 2016.
  • Molecular Biology (3014MSC)
    Teacher, In Person, Gold Coast Campus, Semester 1, 2019.
  • Molecular Medicine (3022MSC)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2019.
  • Molecular Biology (3014MSC)
    Teacher, In Person, Gold Coast Campus, Semester 1, 2018.
  • Molecular Biology (3014MSC)
    Teacher, In Person, Gold Coast Campus, Semester 1, 2017.
  • Molecular Medicine (3022MSC)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2017.
  • Molecular Biology (3014MSC)
    Teacher, In Person, Gold Coast Campus, Semester 1, 2016.
  • Molecular Medicine (3022MSC)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2016.
  • Molecular Biology (3014MSC)
    Convenor, In Person, Gold Coast Campus, Semester 1, 2015.
  • Molecular Biology (3014MSC)
    Teacher, In Person, Gold Coast Campus, Semester 1, 2015.
  • Molecular Medicine (3022MSC)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2015.
  • Molecular Biology (3014MSC)
    Convenor, In Person, Gold Coast Campus, Semester 1, 2014.
  • Molecular Biology (3014MSC)
    Teacher, In Person, Gold Coast Campus, Semester 1, 2014.
  • Molecular Medicine (3022MSC)
    Teacher, In Person, Gold Coast Campus, Semester 2, 2014.
  • Molecular Biology (3014MSC)
    Convenor, In Person, Gold Coast Campus, Semester 1, 2013.
  • Molecular Biology (3014MSC)
    Teacher, In Person, Gold Coast Campus, Semester 1, 2013.
  • Molecular Biology (3014MSC)
    Convenor, In Person, Gold Coast Campus, Semester 1, 2012.
  • Molecular Biology (3014MSC)
    Teacher, In Person, Gold Coast Campus, Semester 1, 2012.

Research by Higher Degree Supervision or Scholarship

Theses Supervised at Griffith

Background

Bio

Track Record PROF NIGEL MCMILLAN
Overview and Current Position. Prof McMillan is a cancer biologist whose research has focused on the interaction between viruses and host cells and novel delivery systems for siRNA. Following his postdoctoral training in the USA (10 papers/356 citations), he established his own laboratory at the University of Queensland (UQ) in 1994 and was appointed a Research Fellow (1998), a Senior Research Fellow (2001), and a Principal Research Fellow in 2009. He is now Professor, Deputy Head of the School of Medical Science, and Director of the Molecular Basis of Disease Program, one of 6 research programs within Griffith Health Institute. This program has over 150 scientists.
Summary of research interests: Prof McMillan is internationally recognized as an expert in the area of RNA interference therapy with major contributions over the last 10 years in the areas of delivery and the interface between RNAi and the immune system. Clinically his lab is interested in treating viral infections, particularly those that result in cancer, such as human papillomavirus. The laboratory takes a multidisciplinary approach to its research work and we have a diverse set of national and international collaborators in the areas of nanoparticle system development, immunology, and cancer biology. This includes international biotechnology companies with whom we have licensed our patents and for whom we undertake contract research. His laboratory has expertise covering the disciplines of molecular biology, cell biology, virology and immunology and focuses on diseases caused by the human papillomavirus. Recent success in nanoparticle delivery has led to an active research program in respiratory viral infections, specifically RSV, Hendravirus and Influenza. Prof McMillan is currently CI on 2 NHMRC grants.
Funding Record. Prof McMillan has had continuous NHMRC grant funding since establishing his laboratory in 1996, and has attracted over $13m in competitive grant funding from national sources (NHMRC, ARC Discovery, Cancer Council, Leukaemia Foundation, Uniseed, Uniquest, and ARC Linkage).
Publication record: Prof McMillan has published 33 papers and reviews since 2010. Publications are in leading journals including papers in PNAS, Clinical Cancer Research, Journal of Virology, Virology, Molecular Therapy, Gene Therapy, Cancer Gene Therapy, Pharm. Research, Journal of Controlled Release, Nature Nanotechnology and Nature Communications. He has >2400 total citations and an average of 37 citations per paper. His paper on the discovery of the HPV receptor (J Virology, 71(3), 2449-2456, 2007) has 332 citations. He has 3 patents, in the areas of siRNA, HPV and novel leukaemia therapies. One is licensed to Alnylam, the leading RNAi company and a major US biotechnology company in Boston.
Leadership and Profile. Prof McMillan has been invited to present work at both national and international meetings. He has received invitations to be Plenary and Keynote speakers at international meetings including RNAi Asia 2010, RNAi World Congress 2011, and the 2nd RNAi Research and Therapeutics Conference. He has been invited to speak at Lorne, Australian Health and Medical Research Congress, OzBio, Endocrine Society, TERMIS, Australian Virology Society, ASM etc. He has served on grant review panels for the European Union Framework 7 and panels for the Queensland Cancer Fund and reviewed grants for the NHMRC, ARC, HRC-NZ, IUAC, RGC Hong Kong and ARC. He is a member of the ARC ERA 2015 evaluation academy. He has been the Conference Convener for 5 national meetings. Prof McMillan was a founding member and Deputy Director of the UQ Diamantina Institute and was instrumental in establishing the RNA Network of Australasia and the Australasian Virology Society, serving as national secretary for both. He is currently Vice-President of the Australasian Virology Society.
Research Training/Mentoring: Prof McMillan has been the supervisor for 18 PhD. candidates, all of whom have gone on to postdoctoral training here or overseas once completed. He has trained 31 Hons or Masters students.
 

Education and Training

  • PhD Doctor of Philosophy, University of Otago 1991
  • BScHons Bachelor Of Science With Honours, University of Otago 1987

Professional memberships

  • President, Australasian Virology Society 2016 - Present