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Contact Don Staines

Email

d.staines@griffith.edu.au

Phone

(07) 373 80524

Campus

G40 9.20, Gold Coast.

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Overview

Research Publications and Outputs

Recent Publications

Publications: 70 (Other: 70)

• Transient Receptor Potential Ion Channels in the Etiology and Pathomechanism of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
• Barnden, L., Shan, Z., Staines, D., Marshall-Gradisnik, S., Finegan, K., Ireland, T., & Bhuta, S. (2018). Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in chronic fatigue syndrome. NeuroImage: Clinical, 20, 102–109.
• Cabanas, H., Eaton-Fitch, N., Khalilidehkordi, E., Broadley, S., Balinas, C., Du Preez, S., … Marshall-Gradisnik, S. (2018). A Pilot Investigation of Natural Killer Cell Function and Phenotypes in Stable and Active Multiple Sclerosis Patients. Journal of Multiple Sclerosis, 5(1), 1000218–1–1000218–7.
• Cabanas, H., Muraki, K., Eaton-Fitch, N., Balinas, C., Staines, D., & Marshall-Gradisnik, S. (2018). Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients. Molecular Medicine, 24(44), 1–10.
• Clarke, L., Broadley, S., Nguyen, T., Johnston, S., Eaton-Fitch, N., Staines, D., & Marshall-Gradisnik, S. (2018). Transient Receptor Potential Melastatin 3 and Intracellular Calcium in Natural Killer Cells in Multiple Sclerosis. International Journal of Clinical Medicine, 9, 541–565.
• Corbitt, M., Campagnolo, N., Staines, D., & Marshall-Gradisnik, S. (2018). A Systematic Review of Probiotic Interventions for Gastrointestinal Symptoms and Irritable Bowel Syndrome in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). Probiotics and Antimicrobial Proteins, 1–12.
• Du Preez, S., Corbitt, M., Cabanas, H., Eaton-Fitch, N., Staines, D., & Marshall-Gradisnik, S. (2018). A Systematic Review of Enteric Dysbiosis in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. Systematic Reviews, 7(241), 1–12.
• Eaton-Fitch, N., Cabanas, H., Balinas, C., Klein, A., Staines, D., & Marshall-Gradisnik, S. (2018). Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation. BMC Pharmacology and Toxicology, 19(1), 12–1–12–9.
• Marshall-Gradisnik, S., Fretel, M., Eaton-Fitch, N., Cabanas, H., Balinas, C., Gopalan, V., … Staines, D. (2018). Decreased Expression of TRPM3 and mAChRM3 in the Small Intestine in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. International Journal of Clinical Medicine, 9(5), 467–480.
• Nguyen, T., Staines, D., Johnston, S., & Marshall-Gradisnik, S. (2018). Reduced glycolytic reserve in isolated natural killer cells from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients: A preliminary investigation. Asian Pacific Journal of Allergy and Immunology, 1–8.
• Shan, Z., Finegan, K., Bhuta, S., Ireland, T., Staines, D., Marshall-Gradisnik, S., & Barnden, L. (2018). Brain function characteristics of chronic fatigue syndrome: A task fMRI study. NeuroImage: Clinical, 19, 279–286.
• Shan, Z., Finegan, K., Bhuta, S., Ireland, T., Staines, D., Marshall-Gradisnik, S., & Barnden, L. (2018). Decreased Connectivity and Increased Blood Oxygenation Level Dependent Complexity in the Default Mode Network in Individuals with Chronic Fatigue Syndrome. Brain Connectivity, 8(1), 33–39.
• Balinas, C., Nguyen, T., Johnston, S., Smith, P., Staines, D., & Marshall-Gradisnik, S. (2017). Investigation of mast cell toll-like receptor 3 in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Systemic Mastocytosis participants using the novel application of autoMACS magnetic separation and flow cytometry. Asian Pacific Journal of Allergy and Immunology, 1–8.
• Campagnolo, N., Johnston, S., Collatz, A., Staines, D., & Marshall-Gradisnik, S. (2017). Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review. Journal of Human Nutrition and Dietetics, 30(3), 247–259.
• Nguyen, T., Johnston, S., Chacko, A., Gibson, D., Cepon, G., Smith, P., … Marshall-Gradisnik, S. (2017). Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients. Asian Pacific Journal of Allergy and Immunology, 35, 75–81.
• Nguyen, T., Johnston, S., Clarke, L., Smith, P., Staines, D., & Marshall-Gradisnik, S. (2017). Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels. Clinical and Experimental Immunology, 187(2), 284–293.
• Shan, Z., Kwiatek, R., Burnet, R., Fante, P. D., Staines, D., Marshall-Gradisnik, S., & Barnden, L. (2017). Medial prefrontal cortex deficits correlate with unrefreshing sleep in patients with chronic fatigue syndrome. NMR in Biomedicine, 1–9.
• Brenu, E., Broadley, S., Nguyen, T., Johnston, S., Ramos, S., Staines, D., & Marshall-Gradisnik, S. (2016). A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis. Journal of Immunology Research, 1–8.
• Chacko, A., Staines, D., Johnston, S., & Marshall-Gradisnik, S. (2016). Dysregulation of Protein Kinase Gene Expression in NK Cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients. Gene Regulation and Systems Biology, 10, 85–93.
• Collatz, A., Johnston, S., Staines, D., & Marshall-Gradisnik, S. (2016). A Systematic Review of Drug Therapies for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. Clinical Therapeutics, 38(6), 1263–1271.e9.
• Huth, T., Brenu, E., Ramos, S., Nguyen, T., Broadley, S., Staines, D., & Marshall-Gradisnik, S. (2016). Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis. Scandinavian Journal of Immunology, 83(1), 44–51.
• Huth, T., Brenu, E., Staines, D., & Marshall-Gradisnik, S. (2016). Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients. Gene Regulation and Systems Biology, 10, 43–49.
• Huth, T., Staines, D., & Marshall-Gradisnik, S. (2016). ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim- natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients. Journal of Translational Medicine, 14, 97–1–97–10.
• Johnston, S., Staines, D., & Marshall-Gradisnik, S. (2016). Epidemiological characteristics of chronic fatigue syndrome/myalgic encephalomyelitis in Australian patients. Clinical epidemiology, 8, 97–107.
• Johnston, S., Staines, D., Klein, A., & Marshall-Gradisnik, S. (2016). A targeted genome association study examining transient receptor potential ion channels, acetylcholine receptors, and adrenergic receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. BMC Medical Genetics, 17(79), 1–7.
• Marshall-Gradisnik, S., Chacko, A., Johnston, S., Smith, P., Nilius, B., & Staines, D. (2016). Genotype Frequencies of Transient Receptor Potential Melastatin M3 Ion Channels and Acetylcholine Muscarinic M3 Receptor Gene Polymorphisms in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients. Immunology and Immunogenetics Insights, 8, 1–2.
• Marshall-Gradisnik, S., Huth, T., Chacko, A., Johnston, S., Smith, P., & Staines, D. (2016). Natural killer cells and single nucleotide polymorphisms of specific ion channels and receptor genes in myalgic encephalomyelitis/chronic fatigue syndrome. Application of Clinical Genetics, 9, 39–47.
• Marshall-Gradisnik, S., Johnston, S., Chacko, A., Nguyen, T., Smith, P., & Staines, D. (2016). Single nucleotide polymorphisms and genotypes of transient receptor potential ion channel and acetylcholine receptor genes from isolated B lymphocytes in myalgic encephalomyelitis/chronic fatigue syndrome patients. Journal of International Medical Research, 44(6), 1381–1394.
• Nguyen, T., Staines, D., Nilius, B., Smith, P., & Marshall-Gradisnik, S. (2016). Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients. Biological Research, 49, 27–1–27–8.
• Ramos, S., Brenu, E., Broadley, S., Kwiatek, R., Ng, J., Nguyen, T., … Marshall-Gradisnik, S. (2016). Regulatory T, natural killer T and γδ T cells in multiple sclerosis and chronic fatigue syndrome/myalgic encephalomyelitis: a comparison. Asian Pacific Journal of Allergy and Immunology, 1–6.
• Shan, Z., Kwiatek, R., Burnet, R., Fante, P. D., Staines, D., Marshall-Gradisnik, S., & Barnden, L. (2016). Progressive Brain Changes in Patients With Chronic Fatigue Syndrome: A Longitudinal MRI Study. Journal of Magnetic Resonance Imaging, 44(5), 1301–1311.
• Hardcastle, S., Brenu, E., Johnston, S., Nguyen, T., Huth, T., Ramos, S., … Marshall-Gradisnik, S. (2015). Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients. Journal of Translational Medicine, 13(1), 299–1–299–9.
• Hardcastle, S., Brenu, E., Johnston, S., Nguyen, T., Huth, T., Ramos, S., … Marshall-Gradisnik, S. (2015). Serum immune proteins in moderate and severe chronic fatigue syndrome/myalgic encephalomyelitis patients. International Journal of Medical Sciences, 12(10), 764–772.
• Hardcastle, S., Brenu, E., Johnston, S., Nguyen, T., Huth, T., Wong, N., … Marshall-Gradisnik, S. (2015). Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). BMC Immunology, 16, 35–1–35–12.
• Marshall-Gradisnik, S., Smith, P., Brenu, E., Nilius, B., Ramos, S., & Staines, D. (2015). Examination of single nucleotide polymorphisms (SNPs) in transient receptor potential (TRP) ion channels in chronic fatigue syndrome patients. Immunology and Immunogenetics Insights, 7, 1–6.
• Marshall-Gradisnik, S., Smith, P., Nilius, B., & Staines, D. (2015). Examination of single nucleotide polymorphisms in acetylcholine receptors in chronic fatigue syndrome patients. Immunology and Immunogenetics Insights, 7, 7–20.
• Peterson, D., Brenu, E., Gottschalk, G., Ramos, S., Nguyen, T., Staines, D., & Marshall-Gradisnik, S. (2015). Cytokines in the Cerebrospinal Fluids of Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. Mediators of Inflammation, 2015, 929720–1–929720–4.
• Ramos, S., Brenu, E., Nguyen, T., Ng, J., Staines, D., & Marshall-Gradisnik, S. (2015). Characterisation of B cell Subsets and Receptors in Chronic Fatigue Syndrome Patients. Journal of Clinical & Cellular Immunology, 6(1), 1000288–1–1000288–5.
• Brenu, E., Ashton, K. J., Batovska, J., Staines, D., & Marshall-Gradisnik, S. (2014). High-throughput sequencing of plasma microRNA in chronic fatigue syndrome/myalgic encephalomyelitis. PlosOne, 9(9), e102783–1–e102783–8.
• Brenu, E., Staines, D., & Marshall-Gradisnik, S. (2014). Methylation Profile of CD4+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. Journal of Clinical & Cellular Immunology, 5(3), 228–1–228–14.
• Fuller, K., Brenu, E., Huth, T., Hardcastle, S., Johnston, S., Nguyen, T., … Marshall-Gradisnik, S. (2014). Comprehensive Analysis of Peripheral B Cell Phenotypes in Chronic Fatigue Syndrome.
• Hardcastle, S., Brenu, E., Johnston, S., Huth, T., Nguyen, T., Ramos, S., … Marshall-Gradisnik, S. (2014). Immune cells in severe and moderate Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.
• Hardcastle, S., Brenu, E., Johnston, S., Huth, T., Ramos, S., Staines, D., & Marshall-Gradisnik, S. (2014). Assessment of severity scales and their use in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.
• Hardcastle, S., Brenu, E., Johnston, S., Huth, T., Ramos, S., Staines, D., & Marshall-Gradisnik, S. (2014). Innate immune cells in severe and moderate Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.
• Hardcastle, S., Brenu, E., Johnston, S., Nguyen, T., Huth, T., Kaur, M., … Marshall-Gradisnik, S. (2014). Alterations in innate and adaptive immune cells in moderate versus severely affected Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.
• Hardcastle, S., Brenu, E., Johnston, S., Nguyen, T., Huth, T., Singh, M. K. B., … Marshall-Gradisnik, S. (2014). Analysis of the Relationship between Immune Dysfunction and Symptom Severity in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). Journal of Clinical & Cellular Immunology, 5(1), 1000190–1–1000190–9.
• Hardcastle, S., Brenu, E., Johnston, S., Nguyen, T., Huth, T., Wong, N., … Marshall-Gradisnik, S. (2014). Perturbations in adhesion molecules and receptors in moderate versus severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients.
• Hardcastle, S., Brenu, E., Johnston, S., Nguyen, T., Kaur, M., Huth, T., … Marshall-Gradisnik, S. (2014). Adaptive immune cells in severe and moderate Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis.
• Hardcastle, S., Brenu, E., Johnston, S., Nguyen, T., Kaur, M., Huth, T., … Marshall-Gradisnik, S. (2014). Analysis of innate immune cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients with varying severities.
• Hardcastle, S., Brenu, E., Johnston, S., Staines, D., & Marshall-Gradisnik, S. (2014). Severity Scales for Use in Primary Health Care to Assess Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. Health Care for Women International, 1–16.
• Hardcastle, S., Brenu, E., Staines, D., & Marshall-Gradisnik, S. (2014). Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and the Potential Role of T Cells. Biological Markers and Guided Therapy, 1(1), 25–38.
• Hardcastle, S., Brenu, E., Wong, N., Johnston, S., Nguyen, T., Huth, T., … Marshall-Gradisnik, S. (2014). Serum cytokines in patients with moderate and severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).
• Hardcastle, S., Brenu, E., Wong, N., Johnston, S., Nguyen, T., Huth, T., … Marshall-Gradisnik, S. (2014). Serum cytokines in patients with moderate and severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).
• Huth, T., Brenu, E., Fuller, K., Hardcastle, S., Johnston, S., Staines, D., & Marshall-Gradisnik, S. (2014). Natural killer cell degranulation and lytic proteins in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.
• Huth, T., Brenu, E., Nguyen, T., Hardcastle, S., Johnston, S., Ramos, S., … Marshall-Gradisnik, S. (2014). Characterization of Natural Killer Cell Phenotypes in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. Journal of Clinical & Cellular Immunology, 5(3), 223–1–223–8.
• Johnston, S., Brenu, E., Hardcastle, S., Huth, T., Fuller, K., Ramos, S., … Marshall-Gradisnik, S. (2014). Immunological, physical and social functioning in varying cases of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.
• Johnston, S., Brenu, E., Hardcastle, S., Huth, T., Staines, D., & Marshall-Gradisnik, S. (2014). A comparison of health status in patients meeting alternative definitions for chronic fatigue syndrome/myalgic encephalomyelitis. Health and Quality of Life Outcomes, 12, 64–1–64–7.
• Johnston, S., Brenu, E., Staines, D., & Marshall-Gradisnik, S. (2014). The role of clinical guidelines for chronic fatigue syndrome/myalgic encephalomyelitis in research settings. Fatigue: Biomedicine, Health & Behavior, 2(1), 28–39.
• Johnston, S., Staines, D., Brenu, E., & Marshall-Gradisnik, S. (2014). Management of Chronic Fatigue Syndrome: Current Approaches and Future Directions. In Chronic Fatigue Syndrome: Risk Factors, Management and Impacts on Daily Life (pp. 79–90). United States: Nova Science Publishers.
• Nguyen, T., Brenu, E., Staines, D., & Marshall-Gradisnik, S. (2014). MicroRNAs in the Intracellular Space, Regulation of Organelle Specific Pathways in Health and Disease. MicroRNA, 3(2), 98–107.
• Peterson, D., Gottschalk, G., Brenu, E., Ramos, S., Hardcastle, S., Staines, D., & Marshall-Gradisnik, S. (2014). A Preliminary Investigation of microRNAs in Cerebrospinal Fluid Samples from Patients with Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis.
• Ramos, S., Brenu, E., Huth, T., Hardcastle, S., Johnston, S., Nguyen, T., … Marshall-Gradisnik, S. (2014). Immunoglobulin Secretion in Chronic Fatigue Syndrome.
• Wong, N., Brenu, E., Hardcastle, S., Johnston, S., Nguyen, T., Huth, T., … Marshall-Gradisnik, S. (2014). Cytokine profiles of chronic fatigue syndrome and multiple sclerosis patients.
• Wong, N., Brenu, E., Hardcastle, S., Johnston, S., Nguyen, T., Huth, T., … Marshall-Gradisnik, S. (2014). Cytokine profiles of chronic fatigue syndrome and multiple sclerosis patients.
• Brenu, E., Atkinson, G., Driel, M. L. van, Kreijkamp-Kaspers, S., Staines, D., & Marshall-Gradisnik, S. (2013). Enhanced Gene Expression Following Vaccination in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. International Journal of Clinical Medicine, 4(3), 165–170.
• Brenu, E., Hardcastle, S., Atkinson, G., Driel, M. van, Kreijkamp-Kaspers, S., Ashton, K., … Marshall-Gradisnik, S. (2013). Natural Killer Cells in Patients with Severe Chronic Fatigue Syndrome. Autoimmunity Highlights, 1–12.
• Brenu, E., Huth, T., Hardcastle, S., Fuller, K., Singh, M. K. B., Johnston, S., … Marshall-Gradisnik, S. (2013). Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis. International Immunology, 26(4), 233–242.
• Brenu, E., Johnston, S., Hardcastle, S., Huth, T., Fuller, K., Ramos, S., … Marshall-Gradisnik, S. (2013). Immune Abnormalities in Patients Meeting New Diagnostic Criteria for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. Journal of Molecular Biomarkers & Diagnosis, 4(3), 1–6.
• Brenu, E., Staines, D., Tajouri, L., Huth, T., Ashton, K., & Marshall-Gradisnik, S. (2013). Heat Shock Proteins and Regulatory T Cells. Autoimmune Diseases, 2013, 813256–1–813256–8.
• Brenu, E., Driel, M. van, Staines, D., Kreijkamp-Kaspers, S., Hardcastle, S., & Marshall-Gradisnik, S. (2012). The Effects of Influenza Vaccination on Immune Function in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. International Journal of Clinical Medicine, 3(6), 544–551.

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Funded Griffith Research

• (2018). Validation of natural killer cell cytotoxic activity in Chronic Fatigue Syndrome/Myalgic Encep halomyelitis following in vitro treatment using anti-CD20 antibody Rituximab
• (2016). Advancement of the NCNED International Clinical and Research Consortium for Chronic Fatigue Syndrome
• (2016). The development of an International Patient Registry to Improve the Case Definition, Diagnosis and management of CFS/ME
• (2014). A multifaceted research design to integrate immunological, radiological and clinical investigations to discover the pathomechanism of CFS and accelerate the diagnosis and implementation of appropriate treatments for patients

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