Overview

Current Work

I am an ARC Future Fellow at the Institute for Glycomics at Griffith University and heading the Institute for Glycomic's Glycoanalytical Mass Spectrometry Facility, which has been established as part of the Australian Centre for Cancer Glycomics (A2CG) in 2017. My major research theme is translating and understanding the glyco-languages that all cells use to communicate to exploit this knowledge for disease diagnosis, treatment and prevention. Though the basic building blocks of the alphabet are similar across all domains of life, we are still on the brink of understanding the individual languages and dialects that cells have evolved. I am particularly interested in understanding how cells are speaking to each other and how pathogens or tumour cells are abusing this language for their evil intentions. Understanding this language is the key to selectively target cells that talk in a different language and to use their dialect to filter them out of the big crowd of cells "talking normally". For this purpose, my team and I have been developing key technologies that allow decoding the cells' glyco-languages. My research naturally requires a multi-disciplinary research approach where we have made great progress in the areas of glycomics and glycoproteomics techniques, in particular in their application on clinically relevant sample material where we were the first ever to report glycome analyses from as low as 1000 cells. In-depth knowledge on naturally occurring glycan structures and their glycoconjugate molecules is fundamental to elucidate the functional and diagnostic aspects hidden in glycan and glycoprotein sequences.  

Expertise Keywords

  • Cancer biology
  • Chromatography
  • Glycan biosynthesis (glycosyltransferases)
  • Glycan recognition (lectins)
  • Glycans
  • Glycobiology
  • Glycointeractome
  • Glycolipids
  • Glycomics
  • Glycoproteins
  • Glycoproteomics
  • Mass Spectrometry
  • Proteins
  • microfluidics
  • nanoLC
  • nanofluidics

Subject Area Codes

  • Analytical Biochemistry
  • BIOLOGICAL SCIENCES
  • Biochemistry and Cell Biology
  • Biological Sciences not elsewhere classified
  • Cancer Cell Biology
  • Characterisation of Biological Macromolecules
  • Enzymes
  • German Language
  • Host-Parasite Interactions
  • Infectious Diseases
  • Medical Biochemistry: Carbohydrates
  • Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)
  • Medicinal and Biomolecular Chemistry
  • Oncology and Carcinogenesis
  • Proteins and Peptides
  • Proteomics and Intermolecular Interactions (excl. Medical Proteomics)
  • Systems Biology

Country Affiliations

  • Austria
  • Germany

Research Publications and Outputs

Recent Publications

Publications: 55 (Other: 55)

Funded Griffith Research

Engagement and Impact

Learning and Teaching

Research by Higher Degree Supervision or Scholarship

Supervision Overview

I currently supervise 2 PhD students and 3 post-doctoral fellows, with a track record of 6 PhD, 6 Master and 3 Bachelor thesis completions at my previous affiliation with the Freie Universität Berlin and the Max Planck Institute of Colloids and Interfaces in Potsdam/Berlin, Germany (2011-2016).
In my group we are always welcoming motivated students.

Background

Bio

I became fascinated with glycobiology and mass spectrometry during my undergraduate studies in Vienna. During my PhD with Professor Friedrich Altmann and his post-doctoral work with Professor Nicolle H. Packer at Macquarie University in Sydney, Australia, I worked intensively on glycopeptide oriented glycoproteomics of human glycoproteins and plant/insect glycoprotein allergens. In late 2010 I took up the opportunity to establish my own independent research group at the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany. There my research was focusing on glycomics and glycoproteomics techniques to investigate the role glycosylation plays in health and disease. I was awarded an ARC future fellowship in late 2016 and I joined the Institute for Glycomics at Griffith University in January 2017 continuing my research in disease and evolutionary glycomics and glycoproteomics.  

Education and Training

  • DSc Doctor of Science, University of Natural Resources and Applied Life Sciences, Vienna 2000 - 2004
  • MSc Master Of Science In Biotechnology, University of Natural Resources and Applied Life Sciences, Vienna 1993 - 2000

Academic experience

  • Research Leader and ARC Future Fellow, Institute of Glycomics, Griffith University 2017 -
  • Group Leader, Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems 2010 - 2016
  • Post Doctoral Research Fellow, Macquarie University 2007 - 2010
  • Post Doctoral Fellow, University of Natural Resources and Applied Life Sciences, Vienna 2004 - 2007
  • PhD Candidate, University of Natural Resources and Applied Life Sciences, Vienna 2000 - 2004

Awards and Honours

  • Future Fellowship, Australian Research Council 2017 -
  • Marie Curie Integration Grant, European Union 2011 - 2015
  • Erwin Schrödinger Fellowship, Austrian Science Fund 2007 - 2008
  • Förderpreis des Theodor Körner Fonds 2005, Arbeiterkammer Wien 2005 - 2005
  • Sanofi-Aventis Price, Medical University Vienna 2008 - 2008

External service roles

  • MIRAGE Board member, MIRAGE Consortium 2011 -

Editorial roles

  • Section Editor - Glycomics & Glycoproteomics, Glycoconjugate Journal 2015 -

Professional memberships

  • Founding Member, Austrian Proteomics Society 2006 - 2009
  • GBM Member and Deputy speaker of the study group "Glycobiology", German Society of Biochemistry and Molecular Biology 2015 - 2016
  • Member, BOKU ALUMNI 2000 -
  • ASMS Member, American Society of Mass Spectrometry 2011 -
  • APS Member, Australian Proteomics Society 2016 -
  • Member, Society for Glycobiology 2017 -