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Professor Smith graduated in Biochemistry from the University of Surrey UK, in 1985 and completed his PhD at Southampton University in 1989. He joined the University of Sussex as a research fellow before being appointed to the faculty as a lecturer in 1993 and becoming Professor in 2002. He went on to serve successively at Sussex, as Director of Graduate Studies for Life Sciences, Head of Chemistry, and Head of the first joint Department of Chemistry and Biochemistry, before joining RMIT. Andy's research career has taken him to California as a NATO Fellow to learn molecular modelling, and to the University of Copenhagen and the BMC Uppsala to learn Structural Biology. Notable achievements in protein biochemistry and biophysics have included the x-ray structure of classical horseradish peroxidase (HRP) published in Nature Structural Biology, and subsequently the structures of HRP in all five oxidation states, published in Nature. The latter included a molecular movie for di oxygen reduction. More recently he elucidated the amino acid centred free radical mechanism of lignin peroxidase published in PNAS, now a paradigm for many of the fungal peroxidases. He has worked extensively with Unilever, Johnson & Johnson and Novozymes and in several large EU consortia, including 'Biorenew', where he was project leader for 'Tailoring Enzyme Activities'. He has enjoyed wide ranging collaborations with a number of leading European research groups and has six patents, including three international filings. In recent years he has become interested in bacterial genomics and reverse genetics as a route for the discovery of new anti-microbial proteins to combat the growing problem of bacterial drug resistance and with others at he is has discovered a novel bacterial protein cyclisation system in strains of Lactobacillus Plantarum. He remains a keen educator and positively enjoys teaching molecular enzymology and biochemistry, especially the wonders of bioenergetics.
GRIFFITH UNIVERSITY APPOINTMENTS
- MemberGriffith Institute for Drug Discovery2017
- Doctor of PhilosophySouthampton University
- Bachelor Of Science With HonoursUniversity of Surey, UK